Result card

  • CUR13: For which health conditions and for what purposes are intravenous immunoglobulins (IVIG) used?
English

For which health conditions and for what purposes are intravenous immunoglobulins (IVIG) used?

Authors: Antonio Migliore, Tapani Keranen, Sinikka Sihvo

Internal reviewers: Kristian Lampe

Since their introduction, IVIG have been proposed as a treatment for an array of disorders, including primary and secondary immune deficiency states, and a variety of autoimmune and inflammatory disorders.

It is suggested that IVIG (0.2 g to 2.0 g per kg bodyweight, any regimen) might have beneficial effects on the pathogenic processes of Alzheimer’s disease {20}, also at the stage of Mild Cognitive Impairment, by interfering positively with metabolism of amyloid β that seems to be reduced in subjects at risk for Alzheimer’s disease. It is hypothesised that IVIG use for passive immunotherapy in Alzheimer’s disease could slow the disease progression {20} {46} and use in patients with Mild Cognitive Impairment could avoid or delay the onset of Alzheimer’s disease {Appendix SAF-1}.

Critical
Completely
Migliore A et al. Result Card CUR13 In: Migliore A et al. Health Problem and Current Use of the Technology In: Jefferson T, Cerbo M, Vicari N [eds.]. Use of Intravenous immunoglobulins for Alzeheimer’s disease including Mild Cognitive Impairment [Core HTA], Agenas - Agenzia nazionale per i servizi sanitari regionali ; 2015. [cited 31 October 2020]. Available from: http://corehta.info/ViewCover.aspx?id=267

References