Result card

  • EFF12: Does use of FIT versus FOBT for CRC screening lead to improved detection of adenomas and CRC?
English

Does use of FIT versus FOBT for CRC screening lead to improved detection of adenomas and CRC?

Authors: Jesús González-Enríquez, Francesca Gillespie, Stefania Lopatriello, Iñaki Imaz

Internal reviewers: Pseudo125 Pseudo125

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A high-quality level systematic review studying differences in detection rates between FIT and gFOBT has been detected {10). This systematic review selected five randomized controlled trials comparing detection rate of advanced neoplasm of FIT vs gFOBT for screening of CRC. The five trials were combined in a meta-analysis using random effects. Colonoscopy was the reference standard. The Pooled detection rates intended to screen cancers and significant adenomas were achieved in 2.23% of individuals with FIT and 1.24 % of individuals with gFOBT. The pooled Odds Ratio of detection with FIT vs. with gFOBT was 1.50 (IC 95%: 0.94-2.39). Hence, the FIT have a 50%, but not significant, higher detection rate in comparison with gFOBT for advanced adenomas and cancer. The existence of heterogeneity (I2: 70.7%) led to use random effects model.

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González-Enríquez J et al. Result Card EFF12 In: González-Enríquez J et al. Clinical Effectiveness In: Jefferson T, Cerbo M, Vicari N [eds.]. Fecal Immunochemical Test (FIT ) versus guaiac-based fecal occult blood test (FOBT) for colorectal cancer screening [Core HTA], Agenas - Agenzia nazionale per i servizi sanitari regionali; 2014. [cited 16 June 2021]. Available from: http://corehta.info/ViewCover.aspx?id=206