Result card

  • EFF2: What is the effect of FIT versus gFOBT for CRC screening on overall mortality?
English

What is the effect of FIT versus gFOBT for CRC screening on overall mortality?

Authors: Jesús González-Enríquez, Francesca Gillespie, Stefania Lopatriello, Iñaki Imaz

Internal reviewers: Pseudo125 Pseudo125

 

Refer to domain search and domain methodology section.

 

We have not identified any study that compares FIT vs gFOBT in terms of mortality. The identified studies that provided mortality information compared screening using FIT vs no screening and reported only colorectal cancer specific mortality. A randomised controlled trial {3} and four observational studies {4, 5, 6, 7} examined the effect of the use of FIT for colorectal cancer screening versus no screening on colorectal cancer mortality or incidence, but not on overall mortality. Tables 1 to 6 and Figure 1 {EFF Appendix 1} extract and evaluate the most important results of the five above mentioned studies. Because of the lack of direct evidence to answer the research question a GRADE profile has not been elaborated.

Important
Completely
González-Enríquez J et al. Result Card EFF2 In: González-Enríquez J et al. Clinical Effectiveness In: Jefferson T, Cerbo M, Vicari N [eds.]. Fecal Immunochemical Test (FIT ) versus guaiac-based fecal occult blood test (FOBT) for colorectal cancer screening [Core HTA], Agenas - Agenzia nazionale per i servizi sanitari regionali; 2014. [cited 16 June 2021]. Available from: http://corehta.info/ViewCover.aspx?id=206

References