Result card

  • CUR4: Which are the known risk factors for acquiring adenomas and/or CRC?

Which are the known risk factors for acquiring adenomas and/or CRC?

Authors: Mirjana Huic, Eleftheria Karampli, Silvia Florescu, Cipriana Mihaescu-Pintia

Internal reviewers: Laura Cacciani, Sophie Brunner, Esther Kraft

Different factors could increase or decrease risk for colorectal cancer (CRC) {1,3,4}.

Factor which increased risk for CRC are: environmental factors (prevalence is increased in developed countries, urban areas); advantaged socioeconomic groups; hypercholesterolemia; coronary artery diseases; low-fiber, high-animal-fat diets; obesity; smoking; acromegaly; sugar consumption; family history (risk is increased in first-degree relatives of patients, families with increased prevalence of cancer, patients with breast or gynaecologic cancer, familial polyposis syndromes);>10-year history of ulcerative colitis or Crohns colitis;>15-year history of uretherosygmoidostomy.

Risk is decreased with long term dietary calcium supplementation, vegetable, garlic, exercise, daily aspirin ingestion (after 5 years daily aspirin there is a 35% reduction in all GI cancers) and other NSAIDs.


Huic M et al. Result Card CUR4 In: Huic M et al. Health Problem and Current Use of the Technology In: Jefferson T, Cerbo M, Vicari N [eds.]. Fecal Immunochemical Test (FIT ) versus guaiac-based fecal occult blood test (FOBT) for colorectal cancer screening [Core HTA], Agenas - Agenzia nazionale per i servizi sanitari regionali; 2014. [cited 16 June 2021]. Available from: